Recent News

Complexa announces Successful Completion of Four Phase 1 Studies of CXA-10 and Planned Phase 2 Initiation in Multiple Orphan Indications during 2016

PITTSBURGH and RADNOR, PA, November 12, 2015 (PRNewswire) -- Complexa Inc., a clinical stage biopharmaceutical company focused on transforming the treatment of fibrosis and inflammatory diseases, today announced the successful completion of an extensive Phase 1 development program for its lead compound CXA-10.

Publications

Sample of over 100 publications available demonstrating extensive and consistently replicated pre-clinical proof-of-concept data and mechanism of action.

Chemistry and Signaling Pathways

Delmastro-Greenwood M, Freeman BA, Wendell SG. 2014. Redox-Dependent Anti-Inflammatory Signaling Actions of Unsaturated Fatty Acids. Annu. Rev. Physiol. 76:79-105.

Kansanen E, Jyrkkänen HK, Volger OL, Leinonen H, Kivelä AM, Häkkinen SK, Woodcock SR, Schopfer FJ, Horrevoets AJ, Ylä-Herttuala S, Freeman BA, Levonen AL. 2009. Nrf2-dependent and –independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid. J Biol Chem 284(48):33233-41.

Kansanen E, Jyrkkänen HK, Volger OL, Leinonen H, Kivelä AM, Häkkinen SK, Woodcock SR, Schopfer FJ, Horrevoets AJ, Ylä-Herttuala S, Freeman BA, Levonen AL. 2009. Nrf2-dependent and –independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid. J Biol Chem 284(48):33233-41. Supplement

Rudolph TK and Freeman FA. 2009. Transduction of Redox Signaling by Electrophile-Protein Reactions. Science Signaling 2:1-13.

Schopfer FJ, Cipollina C, and Freeman BA. 2011. Formation and Signaling Actions of Eletrophilic Lipids. Chemical Reviews 111:5977-6021.

Kidney failure, chronic kidney injury

Liu S, Jia Z, Zhou L, Liu Y, Ling H, Zhou SF, Zhang A, Du Y, Guan G, Yang T. 2013. Nitro-oleic acid protects against adriamycin-induced nephropathy in mice. Am J Physiol Renal Physiol 305(11):F1533-41.

Liu Y, Jia Z, Liu, Downton M, Liu G, Du Y, Yang T. 2013. Combined losartan and nitro-oleic acid remarkably improves diabetic nephropathy in mice. Am J Physiol Renal Physiol 305:F1555-F1562.

Pulmonary hypertension and pulmonary fibrosis

Reddy AT, Lakshmi SP, Kleinhenz JM, Sutliff RL, Hart CM, Reddy RC. 2012. Endothelial cell peroxisome proliferator-activated receptor γ reduces endotoxemic pulmonary inflammation and injury. J Immunol 189(11):5411-20.

Klinke A, Möller A, Pekarova M, Ravekes T, Friedrichs K, Berlin M, Scheu KM, Kubala L, Kolarova H, Ambrozova G, Schermuly RT, Woodco ck SR, Freeman BA, Rosenkranz S, Baldus S, Rudolph V, Rudolph TK. 2014. Protective effects of 10-nitro-oleic acid in a hypoxia-induced murine model of pulmonary hypertension. Am J Respir Cell Mol Biol 51(1):155-62.

Reddy AT, Lakshmi SP, Zhang Y, Reddy RC. 2014. Nitrated fatty acids reverse pulmonary fibrosis by dedifferentiating myofibroblasts and promoting collagen uptake by alveolar macrophages. FASEB J pii: fj.14-256263.

Cardiac fibrosis and hypertrophy

Villacorta L, Guo Y, Zhang J, Converso-Baran K, Schopfer F, Freeman B, Chen YE. 2015  Electrophilic Nitro-Fatty Acids Exert Cardioprotection against Hypertrophic Remodeling and Fibrosis in Pressure overloaded Mice. FASEB 29 (1) Supplement 640.6.

Diabetes, anti-adipogenic and metabolic syndrome

Kelley EE, Baust J, Bonacci G, Golin-Bisello F, Devlin JE, St Croix CM, Watkins SC, Gor S, Cantu-Medellin N, Weidert ER, Frisbee JC, Gladwin MT, Champion HC, Freeman BA, Khoo NK. 2014. Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity. Cardiovasc Res 101(3):352-63.

Schopfer FJ, Cole MP, Groeger AL, Chen CS, Khoo NK, Woodcock SR, Golin-Bisello F, Motanya UN, Li Y, Zhang J, Garcia-Barrio MT, Rudolph TK, Rudolph V, Bonacci G, Baker PR, Xu HE, Batthyany CI, Chen YE, Hallis TM, Freeman BA. 2010. Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids:  selective ligand activity and anti-diabetic signaling actions. J Biol Chem 285(16):12321-33.

Inflammatory bowel disease

Borniquel S, Jansson EA, Cole MP, Freeman BA, Lundberg JO. 2010. Nitrated oleic acid up-regulates PPARgamma and attenuates experimental inflammatory bowel disease. Free Radic Biol Med 48:499-505.