CXA-10 is currently advancing to Phase 2 human studies, to demonstrate disease modifying effects in severe life threatening fibrotic and inflammatory diseases

CXA-10 has demonstrated Proof of Biological Activity from multiple Phase 1 studies. The impact on inflammatory drivers of disease and metabolic effects has also been fully translated from multiple animal models of established disease to Phase 1.

We are currently initiating Proof of Concept Studies in Focal Segmental Glomerulosclerosis (FSGS) and Pulmonary Arterial Hypertension (PAH). Both FSGS and PAH are severe life-threatening diseases that are both driven by inflammation and fibrosis leading to loss of function.

FSGS is a rare disease that attacks the kidney’s filtering units (glomeruli) causing serious ‘protein spilling’ and tissue scarring which leads to permanent kidney damage and even failure. FSGS is one of the causes of a serious condition known as Nephrotic Syndrome. Symptoms of FSGS include proteinuria, edema, low blood albumin levels, high cholesterol and high blood pressure. FSGS may have many different causes. The disease may occur for unknown reasons or because of an infection, or drug, or a disease that affects the entire body, like diabetes, HIV infection, sickle cell disease or lupus. FSGS is progressive and most patients will eventually develop complete renal failure and require dialysis or a kidney transplant to survive.

Pulmonary arterial hypertension (PAH) is a rare, progressive disorder characterized by high blood pressure (hypertension) in the arteries of the lungs (pulmonary artery) for no apparent reason. The pulmonary arteries are the blood vessels that carry blood from the right side of the heart through the lungs. Symptoms of PAH include shortness of breath (dyspnea) especially during exercise, chest pain, and fainting episodes. The exact cause of PAH is unknown. PAH is progressive with the high blood pressure in the lungs causing lung tissue to become fibrotic and the right heart to work much harder, and over time, this heart muscle may weaken or fail.